Micro-cantilevered MEMS Biosensor for Detection of Malaria Protozoan Parasites

Document Type: Research Paper

Authors

1 Department of Electronics & Communication Engineering, Rajiv Gandhi University (A Central University), Itanagar, India

2 Department of Electronics & Communication Engineering, NERIST, Nirjuli, India

Abstract

In this paper, the presented work aims to provide a designed model based on Finite element method for detection of Malaria protozoan parasites. Micro-cantilevers are next generation highly efficient biosensors for detection and prevention of any disease. Here, an E-shaped model for micro cantilevered biosensor is designed using COMSOL Multiphysics specifically for detection of Malaria. Microcantilever materials viz Au, Cu, Si and Pt are used for sensing Malaria protozoan with proper optimization of device structure. The studies were carried out for stress developed and displacement occurred due to force applied through these protozoan biomolecules and varying beam length. Further, the designed structure was analyzed for different beam materials available for biosensor and it was found that Au is best suitable material for detection of malaria protozoan parasites since it has best sensitivity profile among presented materials. The results were also verified through analytical approach and it was found that both results obtained through simulation and analytical methods do closely agree with each other.

Keywords

Main Subjects


[1].   Rebeiz, G. M.,2003RF MEMS, Theory Design and     Technology. Hoboken, New Jersey: Wiley.

[2].   Kurmendra, Kumar R., 2019, MEMS based cantilever biosensors for cancer detection using potential bio-markers present in VOCs: a survey, Microsyst Technol. https://doi.org/10.1007/s00542-019-04326-1

[3].   World Malaria Report (2016) , ISBN: 978 92 4 151171 1, https://www.who.int/malaria/publications/world-malaria-report-2016/report/en/

[4].   Kurmendra, Kumar R, 2017, Design analysis, modeling and simulation of novel rectangular cantilever beam for MEMS sensors and Energy harvesting applications, Int. j. inf. tecnol., 9: 295. https://doi.org/10.1007/s41870-017-0035-6

[5].   Alper Sisman, Etki Gur, Sencer Ozturk, Burak Enez, Bilal Okur, Onur Toker, 2017,  A Low-cost Biomarker-based SAW-Biosensor Design for Early Detection of Prostate Cancer, Procedia Technology, Volume 27, Pages 248-249, ISSN 2212-0173, https://doi.org/10.1016/j.protcy.2017.04.106.

[6].   Keith E. Herold, ‎Avraham Rasooly, 2012, Biosensors and Molecular Technologies for Cancer Diagnostics, CRC Press.

[7].    Vidhya S., Mathew L. ,2009, Design and Analysis of MEMS based Cantilever Sensor for the Detection of Cardiac Markers in Acute Myocardial Infarction. In: Lim C.T., Goh J.C.H. (eds) 13th International Conference on Biomedical Engineering. IFMBE Proceedings, vol 23. Springer, Berlin, Heidelberg

[8].   Y. J. Zhao, A. Davidson, J. Bain, S. Q. Li, Q. Wang and Q. Lin, 2005, A MEMS viscometric glucose monitoring device, the 13th international conference on solid state sensors, Actuators and Microsystems, Digest of technical papers, Transducers’05, Seoul, South Korea, 1816-1819, vol.2, doi: 10.1109/SENSOR.2005.1497447

[9].   Osor Pertin,  Kurmendra, 2018, Pull-in-voltage and RF analysis of MEMS based high performance capacitive shunt switch, Microelectronics Journal,Volume 77, 5-15, 0026-2692 doi:  https://doi.org/10.1016/j.mejo.2018.05.001

[10].Lin F., Rais-Zadeh M., 2016, Tunable RF MEMS Filters: A Review. In: Bhushan B. (eds) Encyclopedia of Nanotechnology. Springer, Dordrecht 

[11].Abdolvand, R.; Bahreyni, B.; Lee, J.E.-Y.; Nabki, F., 2016,  Micromachined Resonators: A Review. Micromachines , 7, 160. 

[12].K. S. N. Murthy, G. R. K. Prasad , N. L. N. V. Saikiran , T. V. S. Manoj, 2016,  Design and Simulation of MEMS Biosensor for the Detection of Tuberculosis,ind. journ. of Sci. and techno., 9, 31.

[13].M. A. Saeed, S. M. Khan, N. Ahmed, M. U. Khan and A. Rehman, 2016, Design and analysis of capacitance-based Bio-MEMS cantilever sensor for tuberculosis detection, International Conference on Intelligent Systems Engineering (ICISE), Islamabad, pp. 175-180. doi:  10.1109/INTELSE.2016.7475116 

[14].M.G.G. Jithendra Prasad, Syed Shameem, 2016, Design and Analysis of Micro-Cantilever Based Biosensor for Swine Flu Detection, International Journal of Electrical and Computer Engineering (IJECE), Vol. 6, No. 3, pp. 1190 ~ 1196 : 2088-8708, DOI: 10.11591/ijece.v6i3.9446

[15].Stoney, G. G., 1909, The Tension of Metallic Films Deposited by Electrolysis, Proc. R. Soc. London, Ser. A, 82, pp. 172–175.

[17].M Mohammadi, M Ghayour, A Farajpour, 2013, Free transverse vibration analysis of circular and annular graphene sheets with various boundary conditions using the nonlocal continuum plate model, Composites Part B: Engineering 45 (1), 32-42

[18].M Danesh, A Farajpour, M Mohammadi, 2012, Axial vibration analysis of a tapered nanorod based on nonlocal elasticity theory and differential quadrature method, Mechanics Research Communications 39 (1), 23-27.

[19].A Farajpour, M Mohammadi, AR Shahidi, M Mahzoon, 2011, Axisymmetric buckling of the circular graphene sheets with the nonlocal continuum plate model, Physica E: Low-dimensional Systems and Nanostructures 43 (10), 1820-1825

[20].A Farajpour, MRH Yazdi, A Rastgoo, M Mohammadi, 2016, A higher-order nonlocal strain gradient plate model for buckling of orthotropic nanoplates in thermal environment, Acta Mechanica 227 (7), 1849-1867.

[21].A Farajpour, MRH Yazdi, A Rastgoo, M Loghmani, M Mohammadi, 2016, Nonlocal nonlinear plate model for large amplitude vibration of magneto-electro-elastic nanoplates, Composite Structures 140, 323-336

[22].M Mohammadi, A Farajpour, A Moradi, M Ghayour,2014,  Shear buckling of orthotropic rectangular graphene sheet embedded in an elastic medium in thermal environment, Composites Part B: Engineering 56, 629-637

[23].A Farajpour, M Danesh, M Mohammadi, 2011, Buckling analysis of variable thickness nanoplates using nonlocal continuum mechanics, Physica E: Low-dimensional Systems and Nanostructures 44 (3), 719-727

[24].SR Asemi, A Farajpour, M Mohammadi, 2014, Nonlinear vibration analysis of piezoelectric nanoelectromechanical resonators based on nonlocal elasticity theory, Composite Structures 116, 703-712

[25]., H Moosavi, M Mohammadi, A Farajpour, SH Shahidi, 2011, Vibration analysis of nanorings using nonlocal continuum mechanics and shear deformable ring theory, Physica E: Low-dimensional Systems and Nanostructures 44 (1), 135-140

[26].M Mohammadi, M Goodarzi, M Ghayour, A Farajpour, 2013, Influence of in-plane pre-load on the vibration frequency of circular graphene sheet via nonlocal continuum theory, Composites Part B: Engineering 51, 121-129

[27].MR Farajpour, A Rastgoo, A Farajpour, M Mohammadi, 2016, Vibration of piezoelectric nanofilm-based electromechanical sensors via higher-order non-local strain gradient theory, Micro & Nano Letters 11 (6), 302-307

[28].A Farajpour, A Rastgoo, M Mohammadi, 2014, Surface effects on the mechanical characteristics of microtubule networks in living cells, Mechanics Research Communications 57, 18-26

[29].M Mohammadi, M Safarabadi, A Rastgoo, A Farajpour, 2016, Hygro-mechanical vibration analysis of a rotating viscoelastic nanobeam embedded in a visco-Pasternak elastic medium and in a nonlinear thermal environment, Acta Mechanica 227 (8), 2207-2232

[30].M Goodarzi, M Mohammadi, A Farajpour, M Khooran, 2014,  Investigation of the effect of pre-stressed on vibration frequency of rectangular nanoplate based on a visco-Pasternak foundation, JOURNAL OF SOLID MECHANICS 6 (1), 98-121

[31].SR Asemi, M Mohammadi, A Farajpour, 2014, A study on the nonlinear stability of orthotropic single-layered graphene sheet based on nonlocal elasticity theory, Latin American Journal of Solids and Structures 11 (9), 1515-1540

[32].M Mohammadi, A Farajpour, M Goodarzi, H Mohammadi, 2013, Temperature effect on vibration analysis of annular graphene sheet embedded on visco-Pasternak foundation, Journal of Solid Mechanics 5 (3), 305-323

[33].M Safarabadi, M Mohammadi, A Farajpour, M Goodarzi, 2015, Effect of surface energy on the vibration analysis of rotating nanobeam, Journal of Solid Mechanics 7 (3), 299-311

[34].M Goodarzi, M Mohammadi, M Khooran, F Saadi,2016,  Thermo-mechanical vibration analysis of FG circular and annular nanoplate based on the visco-pasternak foundation, Journal of Solid Mechanics Vol 8 (4), 788-805

[35].M Mohammadi, M Ghayour, A Farajpour, 2011, Analysis of free vibration sector plate based on elastic medium by using new version differential quadrature method, Journal of solid mechanics in engineering 3 (2), 47-56

[36].M Mohammadi,A. Rastgoo, 2018, Primary and secondary resonance analysis of FG/lipid nanoplate with considering porosity distribution based on a nonlinear elastic medium , Mechanics of Advanced Materials and Structures, DOI: 10.1080/15376494.2018.1525453

[37].M. Mohammadi and A. Rastgoo, 2019,  Nonlinear vibration analysis of the viscoelastic composite nanoplate with three directionally imperfect porous FG core, structural engineering and mechanics, pages 131-143. DOI: 10.12989/sem.2019.69.2.131

[38].Kurmendra, R. Kumar, 2019, Design and Simulation of MEMS shunt capacitive switch for lower switching time, Special Issue (2019): 3C TECHNOLOGY - EDITION 28-2. DOI: 10.17993/3ctecno.2019.specialissue.15

[39].Kurmendra, Kumar R., Pertin O. , 2019, Design of An Improved Micro-Electro-Mechanical-Systems Switch for RF Communication System. In: Khare A., Tiwary U., Sethi I., Singh N. (eds) Recent Trends in Communication, Computing, and Electronics. Lecture Notes in Electrical Engineering, vol 524. Springer, Singapore DOI: https://doi.org/10.1007/978-981-13-2685-1_1

[40].A. Chamuah, Kurmendra and R. Kumar, 2018, A Novel Structure for Piezoelectric Based MEMS Energy Harvester, 5th IEEE Uttar Pradesh Section International Conference on Electrical, Electronics and Computer Engineering (UPCON), Gorakhpur, 2018, pp. 1-4.
doi: 10.1109/UPCON.2018.8596823