Transforming Medical Manufacturing: Groundbreaking Innovations Redefining Healthcare
Document Type : Research Paper
Authors
1 Department of Mechanical Engineering, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ, 07030, USA
2 Department of Mechanical & Biomedical Engineering, Boise State University, Boise, ID, USA
3 Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, Turin 10129, Italy
Abstract
This paper presents a thorough examination of recent progressions in additive manufacturing (AM) methodologies utilized within the biomedical realm, with particular attention to tissue engineering. Additive manufacturing provides exceptional precision in producing intricate three-dimensional objects using a variety of materials. Techniques such as Jetting, Material Extrusion, Material Jetting, Powder Bed Fusion, Sheet Lamination, and Vat Polymerization are strategically employed in biomedical applications to fulfill specific component requirements. Our focus is on polymer materials, encompassing both natural and synthetic variants, exploring the use of hydrogels for scaffold fabrication. We critically analyze the mechanical properties of these polymer scaffolds to enhance personalized patient care and mitigate implantation risks. Through careful adjustment of process parameters, this study illustrates the feasibility of achieving improved mechanical properties in manufactured components. This comprehensive review contributes to the ongoing discussion on advanced manufacturing methods for polymeric scaffolds in medical contexts, offering valuable insights for researchers, practitioners, and industry experts.
Keywords
- Additive manufacturing
- Polymeric scaffold
- Material Jetting
- Powder Bed Fusion
- Manufactured components
- Tissue engineering
Main Subjects
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[8] R. Winarso, P. Anggoro, R. Ismail, J. Jamari, A. Bayuseno, Application of fused deposition modeling (FDM) on bone scaffold manufacturing process: a review, Heliyon, Vol. 8, No. 11, 2022.
[9] A. Abdullah, F. Shahabipour, A. Shaito, S. Al-Assaf, A. A. Elnour, E. B. Sallam, S. Teimourtash, A. A. Elfadil, 3D hydrogel/bioactive glass scaffolds in bone tissue engineering: Status and future opportunities, 2023.
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[13] A. Farazin, M. Mohammadimehr, H. Naeimi, Flexible self-healing nanocomposite based gelatin/tannic acid/acrylic acid reinforced with zinc oxide nanoparticles and hollow silver nanoparticles based on porous silica for rapid wound healing, International Journal of Biological Macromolecules, Vol. 241, pp. 124572, 2023.
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[15] M. Y. Khalid, Z. U. Arif, R. Noroozi, M. Hossain, S. Ramakrishna, R. Umer, 3D/4D printing of cellulose nanocrystals-based biomaterials: Additives for sustainable applications, International Journal of Biological Macromolecules, pp. 126287, 2023.
[16] Z. Huang, G. Shao, L. Li, Micro/nano functional devices fabricated by additive manufacturing, Progress in Materials Science, Vol. 131, pp. 101020, 2023.
[17] A. Zarei, A. Farazin, Synergizing additive manufacturing and machine learning for advanced hydroxyapatite scaffold design in bone regeneration, Journal of the Australian Ceramic Society, 2024/08/26, 2024.
[18] N. Venishetty, M. Toutoungy, J. Beale, J. Martinez, D. K. Wukich, V. Mounasamy, M. H. Huo, S. Sambandam, Total hip arthroplasty in nonagenarians–a national in-patient sample-based study of perioperative complications, Geriatric Orthopaedic Surgery & Rehabilitation, Vol. 14, pp. 21514593231178624, 2023.
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[20] F. Otaola, C. de Lartigue, V. Fitzpatrick, D. Luart, M. Leturia, E. Guenin, C. Egles, Additive Manufacturing of Biomaterials, Biomaterials and Tissue Engineering, pp. 331-355, 2023.
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[22] M. Ramezani, Z. Mohd Ripin, 4D printing in biomedical engineering: Advancements, challenges, and future directions, Journal of functional biomaterials, Vol. 14, No. 7, pp. 347, 2023.
[23] S. Tavasolikejani, A. Farazin, Explore the most recent advancements in the domain of self-healing intelligent composites specifically designed for use in dentistry, Journal of the Mechanical Behavior of Biomedical Materials, pp. 106123, 2023.
[24] T. Mahmood, A. Shahbaz, N. Hussain, R. Ali, H. Bashir, K. Rizwan, Recent advancements in fusion protein technologies in oncotherapy: A review, International Journal of Biological Macromolecules, Vol. 230, pp. 123161, 2023.
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Volume 56, Issue 1
January 2025Pages 1-14
- Receive Date: 20 October 2024
- Revise Date: 06 November 2024
- Accept Date: 11 November 2024