TY - JOUR ID - 70479 TI - Influence of taxol and CNTs on the stability analysis of protein microtubules JO - Journal of Computational Applied Mechanics JA - JCAMECH LA - en SN - 2423-6713 AU - Rohani Rad, Elaheh AU - Farajpour, Mohammad Reza AD - Faculty of Health and Medical Sciences, Adelaide Medical School, University of Adelaide, Adelaide, Australia AD - Borjavaran Center of Applied Science and Technology, University of Applied Science and Technology, Tehran, Iran Y1 - 2019 PY - 2019 VL - 50 IS - 1 SP - 140 EP - 147 KW - Protein microtubules KW - stability analysis KW - Taxol KW - Carbon nanotubes DO - 10.22059/jcamech.2019.277874.369 N2 - Microtubules are used as targets for anticancer drugs due to their crucial role in the process of mitosis. Recent studies show that carbon nanotubes (CNTs) can be classified as microtubule-stabilizing agents as they interact with protein microtubules (MTs), leading to interference in the mitosis process. CNTs hold a substantial promising application in cancer therapy in conjunction with other cancer treatments such as radiotherapy and chemotherapy. In the current study, a size-dependent model is developed for the stability analysis of CNT-stabilized microtubules under radial and axial loads. A nonlocal shell theory with strain gradient effects is employed to take size influences into account. Moreover, Van der Waals interactions between CNTs and MTs are simulated. An excellent agreement is observed between the present model and reported data from experiments on protein MTs. In addition, the effects of taxol, as another stabilizing agent, on the stability of microtubules are studied. It is found that both nonlocal and strain gradient effects are essential to accurately obtain the stability capacity of MTs. Furthermore, CNTs have an increasing effect on the critical loads of microtubules while the critical loads reduce in the presence of taxol. UR - https://jcamech.ut.ac.ir/article_70479.html L1 - https://jcamech.ut.ac.ir/article_70479_e1b28a25a9c561780be8b40921b7699e.pdf ER -